Receptor Grade, Human Recombinant

Insulin-Like Growth Factor-1 Long R3

Highly Purifed Insulin-Like Growth Factor-1 Proteins Synthesized Under Strict High-Level Quality Control Protocols and Purification Processes at our State of the Art Laboratory.

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Long Arg3 IGF-1 Protein Structure

IGF-1 LR3 (Insulin-Like Growth Factor-1 Long Arg3)

IGF-1 LR3, also known as Long R3 IGF-1, is a recombinant protein analogue of human Insulin-Like Growth Factor-1 (rHIGF-1) that has a molar mass of 9,200 Daltons and is comprised of 83 amino acids. IGF1 LR3 comprises the complete IGF-1 sequence, but with the addition of a 13 amino acid extension on the B-Terminus domain and the substitution of an Arginine (Arg) for the Glutamic Acid (Glu) at position 3, hence the name Long R3. The LR3 analogue of IGF-1 was created with the intent to drastically increase the biological activity of the protein and research has demonstrated that IGF-LR3 is several times more potent than rhIGF-1 both in vivo and in vitro. This specific sequence alteration has decreased the affinity of binding to the IGFBPs, which control the biological actions of IGF-1 and prevent the protein from reaching the IGF-1 receptors. Resultantly, Human IGF-1 LR3 binds to the type 1 IGF-1 receptor with similar affinity to that of wild type IGF-1, but with higher biological activity and increased intracellular signaling.

Receptor Grade Insulin-Like Growth Factor-1 Long R3 and Increased Biological Activity

IGF1LR3.com offers genuine Receptor Grade IGF-1 LR3, which is a high quality research protein reagent for use in studies on cell growth, IGF-1 receptors and IGF-1 binding proteins and is more potent than rH IGF-1 both in vivo and in vitro due to the drastic increase in biological activity (stronger affinity for binding with the IGF receptor) and high-level purity. This combination of increased biological activity and purity is what sets Receptor Grade IGF-1 LR3 apart from standard IGF-1. By resisting IGFBP-binding, IGF-1 LR3 has a greater physiologic effect than IGF-1 does, particularly in tissues with high IGFBPs. IGF1-LR3 encourages both an increase in as well as a distinction of stem cells. Additionally, Long-R3 IGF-1 increases satellite cell activity, muscle DNA, muscle protein content, muscle weight and muscle cross sectional area. IGF-1 LR3’s effects stem from the growth factor’s promotion of nitrogen retention and protein synthesis and these two effects combine to stimulate the growth of muscle tissue through hyperplasia and mitogenesis.

Premium IGF-1 Protein and Peptide Analogues Synthesized at State of the Art Laboratories

Insulin-Like Growth Factor-1 is a polypeptide hormone that structurally and molecularly shares some properties with Insulin, which requires specialized recombinant synthesis technology to manufacture correctly. Complex proteins, such as IGF-1 LR3 and IGF-1 DES (1-3), are commonly produced in E.coli. and then scaled up to produce a highly-purified, lyophilized protein end product. Proprietary synthesis procedures are implemented to ensure that the tertiary structure encompasses all of the correct folds, polypeptide interactions and amino acid side chains so that the biological activity of the desired IGF-1 protein is of the highest possible level. At IGF1LR3.com, our synthesis laboratories spare no expense when it comes to Insulin-Like Growth Factor-1 quality and all of our products are subject to extensive quality control and purification protocols, which enables us to continuously offer highly-purified and biologically active IGF-1 proteins and peptide analogues to our customers and pushes our product line ahead of the competition.

IGF1LR3.com - The Leading Supplier of Highly Purified IGF-1 Proteins and Peptides

IGF1LR3.com is an online supplier of IGF-1 LR3 and other Insulin-Like Growth Factor-1 proteins and peptides that are manufactured under strict high-level quality control processes, with Multi-Stage RP-HPLC and MS Analyses performed following the completion of protein synthesis and purification. Our company spares no expense when it comes to product quality and our synthesis laboratories are capable of fulfilling IGF-1 orders of all sizes, from milligram to kilogram, and we offer fast, reliable, professional and discreet shipping worldwide. Our quality standards are as thorough as they are uncompromising, enabling our company to provide our customers with only Receptor-Grade IGF-1 LR3 that has been assayed at a minimum of 98% purity. Our company is fervently engaged in the quest to uncover the exciting possibilities presented by the utilization of IGF-1 LR3 proteins and peptides in future applications, and we are dedicated to providing only the best quality products to professionals in the scientific community.